Comparison of Injectable Phenytoin and Laveracetam in Control of Neonatal Seizure due to Hypoxic Ischemic Encephalopathy

Objectives: To compare the efficacy of leviracetam and phenytoin as a sole agent in control neonatal seizure due to grade II HIE. Methodology: A Prospective comparative study was conducted ICU Combined Military Hospital Malir Cantt for 7 months from June 2020 Dec 2020. Total 60 cases HIE perinatal asphyxia were reported during period enrolled using simple consecutive sampling technique. Their demographic data, clinical features frequencies selected known risk factors recorded. The samples randomized into two groups alternate Group given I/V Phenytoin while group B Laveracetam. response measured terms with single drug. Results: Out neonates 35(58.33 %) preterm. Observed included gestational diabetes 14(23.3%), pregnancy induced hypertension 10(16.7%), meconium stained liquor 9(15%), fetal bradycardia 8(13.3%) maternal infections 2(3.3%). alone controlled seizures 22 (73.3%) found significantly better than Laveracetam which 19(63.3%) cases. (P-value < 0.001) Conclusion: Perinatal is more common preterm neonates. Gestational most factor asphyxia. first line antiepileptic